Department of Population Medicine & Diagnostic Sciences at the Cornell University College of Veterinary Medicine

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Bettina Wagner

Assistant Professor of Immunology

Dept. of Population Medicine and Diagnostic Sciences
College of Veterinary Medicine
Cornell University
Ithaca, New York 14853

bw73@cornell.edu

Our laboratory focuses on research in veterinary immunology. We are particularly interested in protective mechanisms and cytokine regulation during immune responses to intracellular pathogens and allergic reactions. Other major goals are the development of advanced technologies in veterinary diagnostics and immune reagents for veterinary species.

For more information, please view the Wagner Lab web site.

Education

Patent Submissions

Honors and Awards

Research and Professional Experience

Professional Society Memberships

Selected Publications

Education

DVM	- 1990	Veterinary Medicine - School of Veterinary Medicine, Hannover, Germany
Dr.vet.med	- 1993	Veterinary Immunology - School of Veterinary Medicine, Hannover, Germany
Post-doctoral fellow	- 1994	Genetics: Isolation and characterization of IGHC genes of the horse - Institute for Genetics, University of Cologne, Germany
Habilitation	- 2006	Immunology - School of Veterinary Medicine, Hannover, Germany

Patent Submissions

		2001			Non-disclosed patent application No. 100 64 415.5-41 submitted 12/21/00 (Germany), No. 01984722.7-2405-DE0104810 submitted 12/20/01 (European Union). “Method to generate recombinant immunoglobulins, respective DNA and expression systems and their use to generate monoclonal antibodies recognizing native immunoglobulin isotypes.” Inventors: B. Wagner, A. Radbruch and W.Leibold / applicants: School of Veterinary Medicine, Hannover, Germany, DE
		2003			Non-disclosed patent application No. 10/451.078 submitted 6/19/03 (United States of America), “Desoxyribonucleic acids for coding for the equine IgE-allotype heavy chain constant region, the recombinant immunoglobulins obtained therewith and corresponding isotype-specific monoclonal antibodies and the utilization thereof.” Inventors: B. Wagner, A. Radbruch and W.Leibold / applicants: School of Veterinary Medicine, Hannover, Germany, DE

Honors and Awards

2002-2003

Research exchange grant from the Max Kade Foundation, Inc., New York, NY, USA

Research and Professional Experience

		1994-2002			Assistant Professor of Immunology, School of Veterinary Medicine, Hannover, Germany
		2002-2004			Visiting Professor, Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
		2004-2006			Senior Research Associate, Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
		2006-present			Assistant Professor of Immunology, Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
		2006-present			Director of Automated Serology, Animal Health Diagnostic Center, Cornell University, Ithaca, NY, USA

Professional Society Memberships

		2001-present			Member of the DGfI (German Society of Immunology)
		June 2003			Co-organizer, Havemeyer Foundation Workshop, “Genomic Applications to Equine Immunity,” Cornell University, June 19-22, 2003
		2004-present			Member of the American Association of Immunologists (AAI)
		2005-present			Member of the AAI Veterinary Immunology Committee
		2006			Junior Faculty Travel Award, American Association of Immunologists

Selected Publications

Peer-reviewed articles
	1.	Wagner B, Radbruch A, Richards C and Leibold W. 1995. Monoclonal equine IgM and IgG immunoglobulins. Vet. Immunol. Immunopathol., 47: 1-12.
	2.	Wagner B , Brandt K, Sheoran A, Holmes MA, Deegen E and Leibold W. 1997. Immunoglobulinisotypes in the vitreous of horses with and without recurrent uveitis. Dtsch. tierärztl. Wschr., 104: 467-470.
	3.	Wagner B , Siebenkotten G, Leibold W and Radbruch A. 1997. Organization of the equine immunoglobulin constant heavy chain genes. I. ce and ca genes. Vet. Immunol. Immunopathol., 60: 1-13.
	4.	Wagner B , Overesch G, Sheoran AS, Holmes MA, Richards C, Leibold W and Radbruch A. 1998. Organization of the equine immunoglobulin heavy chain constant region genes. III. Alignment of cµ, cg, ce and ca genes. Immunobiology, 199: 105-119.
	5.	Overesch G, Wagner B, Radbruch A and Leibold W. 1998. Organization of the equine immunoglobulin constant heavy chain genes. II. Equine cg genes. Vet Immunol. Immunopathol., 66: 273-287.
	6.	Eule JC, Wagner B, Leibold W und Deegen E. 2000. Occurrence of different immunoglobulin isotypes in horses with equine recurrent uveitis (ERU). Berl. Münch. Tierärztl. Wschr., 113: 253-257.
	7.	Dohmann K, Wagner B, Horohov DW and Leibold W. 2000. Expression and characterisation of equine interleukin 2 and interleukin 4. Vet. Immunol. Immunopathol., 77: 243-256.
	8.	Wagner B , Siebenkotten G, Radbruch A and Leibold W. 2001. Nucleotide sequence and restriction fragment length polymorphisms of the equine Ce gene. Vet. Immunol. mmunopathol., 82: 193-202.
	9.	Steinbach F, Deeg C, Mauel S and Wagner B. 2002. Equine immunology: offspring of the serum horse. Trends in Immunol., 23: 223-225.
	10.	Wagner B, Greiser-Wilke I, Wege A, Radbruch A and Leibold W. 2002. Evolution of the six equine IGHG genes and corresponding immunoglobulin gamma heavy chains. Immunogenetics, 54: 353-364.
	11.	Wagner B, Siebenkotten G, Leibold W and Radbruch A. 2002. Expression of a 4-(Hydroxy-3-nitro-phenyl) acetyl (NP) specific equi-murine IgE antibody that mediates histamine release in vitro and a type I skin reaction in vivo. Equine Vet. J., 34: 657-665.
	12.	Grummer B, Bendfeldt S, Wagner B and Greiser-Wilke I. 2002. Induction of the intrinsic apoptotic pathway in cells infected with cytopathic bovine virus diarrhoea virus. Virus Research, 90: 143-153.
	13.	Wagner B, Radbruch A, Rohwer J and Leibold W. 2003. Monoclonal anti-equine IgE antibodies with specificity for different epitopes on the immunoglobulin heavy chain of native IgE. Vet. Immunol. Immunopathol., 92: 45-60.
	14.	Wagner B, Greiser-Wilke I and Antczak DF. 2003. Characterization of the horse (Equus caballus) IGHA gene. Immunogenetics, 55:552-560.
	15.	Ainsworth DM, Grunig G, Matychak MB, Young J, Wagner B, Erb HN and Antczak DF. 2003. Recurrent airway obstruction (RAO) in horses is characterized by INF-g and IL-8 production in bronchoalveolar lavage cells. Vet Immunol Immunopath, 96:83-91.
	16.	Wagner B, Miller DC, Lear TL and Antczak DF. 2004. The complete map of the Ig heavy chain constant gene region reveals evidence for seven IgG isotypes and for IgD in the horse. J. Immunol., 173: 3230-3242.
	17.	Desjardins I, Théoret C, Joubert P, Wagner B and Lavoie J-P. Comparison of TGF-beta 1 concentrations in bronchoalveolar fluid of horses affected with heaves and of normal controls. Vet. Immunol. Immunopath.,101:133-141.
	18.	Xu J, Lasry J.B, Svaren J, Wagner B and Darien BJ. 2005. Identification of equine P-selectin glycoprotein ligend-1 (CD162). Mamm. Genome, 16:66-71.
	19.	Wagner B, Robeson J, McCracken M, Wattrang E and Antczak DF. 2005. Horse cytokine/IgG1 fusion proteins – mammalian expression of biologically active cytokines and a system to verify antibody specificity to equine cyotokines. Vet. Immunol. Immunopath., 105:1-14.
	20.	Wagner B. 2006. Immunoglobulins and immunoglobulin genes of the horse. Dev. Comp. Immunol., 30: 155-164.
	21.	Wagner B, Flaminio JBF, Hillegas J, Leibold W, Erb HN and Antczak DF. 2006. Occurrence of IgE in foals: evidence for transfer of maternal IgE by the colostrum and late onset of endogenous IgE production in the horse. Vet. Immunol. Immunopathol., 110: 269-278.
	22.	Wagner B, Hillegas JM and Antczak DF. 2006. A monoclonal antibody to equine interleukin 4. Vet. Immunol. Immunopathol., 110: 363-367.
	23.	Ainsworth DM, Wagner B, Franchini M, Grunig G, Erb HN, Tan J-Y. 2006. Time-dependent alterations in interleukin-8 gene expression in the bronchial epithelium of horses with recurrent airway obstruction (RAO). Am. J. Vet. Res., 67: 669-677.
	24.	Goodman LB, Wagner B, Flaminio MJ, Sussman KH, Metzger SM, Holland R, Osterrieder N. 2006. Comparison of the efficacy of inactivated combination and modified-live virus vaccines against challenge infection with neuropathogenic equine herpesvirus type 1 (EHV-1). Vaccine, 24: 3636-3645.
	25.	Wagner B, Miller WH, Morgan EE, Hillegas JM, Erb HN, Leibold W, Antczak DF. IgE and IgG antibodies in skin allergy of the horse. Vet. Res., 37: 813-825.

Last Update January 7, 2008