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Yrjö T. Gröhn
Professor of Epidemiology and Chair
Department of Population Medicine and Diagnostic Sciences
College of Veterinary Medicine
Cornell University
Ithaca, New York 14853
607-253-4136, ytg1@cornell.edu


My research interests have evolved from studies of basic metabolism in ruminants and genetics to veterinary epidemiology, economic modeling and food safety. The two main areas of investigations currently ongoing in my laboratory are: 1) optimizing dairy herd health and management decisions, and 2) mathematical modeling of zoonotic infectious diseases (such as L. monozytogenes, salmonellosis, Johne’s). Both of these areas of research offer opportunities for training in epidemiological and mathematical modeling, genetic analysis and economic methods.
Education

1973 B.V.M., College of Vet. Med., Helsinki, Finland
1977 D.V.M., College of Vet. Med., Helsinki, Finland
1980 Food Hygienist, College of Vet Med, Helsinki, Finland
1982 M.P.V.M., in Epidemiology, University of California, Davis
1983 M.S., in Genetics, University of California, Davis
1985 Ph.D., in Vet. Med., College of Vet. Med., Helsinki
2002 Diplomate ECVPH (European College of Vet. Public Health)




Research and Professional Experience
2002-present    Chair, Dept. of Population Medicine and Diagnostic Sciences, Cornell University
2001-2002    Acting Chair, Dept. of Population Med and Diagnostic Sciences, Cornell University
1998 -2001    Assoc. Chair, Dept. of Population Medicine and Diagnostic Sciences, Cornell University
1995 - 2001    Chief, Section of Epidemiology, Cornell University, Ithaca, NY
1994 - 1995    Visiting Professor, F.C. Donders Chair, University of Utrecht, Utrecht, The Netherlands
1993 – 1994    Chief, Section of Epidemiology, Cornell University, Ithaca, NY
1993 -    Docent of Epidemiology, College of Veterinary Medicine, Helsinki, Finland
1988-present    Assistant, Associate, and Full Professor of Epidemiology, College of Veterinary Medicine, Cornell University
1988 - 1991    Associate Professor, Dept. of Animal Hygiene, College of Vet. Med.,Helsinki, Finland
1986 - 1988    Post doc, Visiting Assistant Professor, Section of Epidemiology, Dept. of Clin. Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY



Honors and Awards
1981-1982    Kellogg Fellow
   Phi Zeta, Veterinary Medicine
   Sigma Xi, American Research Association
   Gamma Sigma Delta, The Honor Society of Agriculture
1994-1995    F.C.Donders Chair, University of Utrecht, August, 1994 - July, 1995
1999    Samuel F. Scheidy Memorial Award
2007    The Gareth Davies lecture



Professional Society Memberships

American Dairy Science Association
American Veterinary Medical Association
Association of Teachers of Veterinary Public Health and Preventive Medicine
Finnish Veterinary Medical Association
New York State Veterinary Medical Society
Nordic Association of Veterinary Epidemiology




Selected Publications (2006-present)

Hu, Y., Gall, K., Ho, A. J., Ivanek, R. Gröhn, Y. T., and Wiedmann, M. 2005. Daily variability of Listeria contamination patterns in a cold-smoked salmon processing operation. J. Food Prot., 2006, 69: 2123-2133.

Wang, C., Turnbull, B., Gröhn, Y. T., and Nielsen, S.S.: Estimating ROC curves with covariates when there is no perfect reference test for diagnosis of Johne’s Disease. J. Dairy Sci., 2006, 89: 3038-3046.

Ivanek, R, Gröhn, Y.T., Wiedmann, M.: Listeria monocytogenes in multiple habitats and host populations: review of available data for mathematical modeling. Foodborne Pathogens and Disease, 2006, 3: 319-336.

Alcaine, S. D., Y. Soyer, L. D. Warnick, W.-L. Su, S. S. Sukhnanand, J. Richards, E. D. Fortes, P. McDonough, T. P. Root, N. B. Dumas, Y. T. Gröhn, and M. Wiedmann. 2006. Multilocus sequence typing supports that cattle and human associated Salmonella represent distinct and overlapping populations. Appl. Environ. Micro. 2006, 72: 7575-7585.

Haugan, T., Gröhn, Y. T., Kommisrud, E., Ropstad, E., and Reksen, O.: Effects of sperm concentration at semen collection and storage period of frozen semen on dairy cow conception. Anim Reprod Sci. 2007, 97: 1-11.

Ivanek, R, Gröhn, Y.T., Ho, A. J., and Wiedmann, M.: Markov chain approach to analyze the dynamics of pathogen fecal shedding -Example of Listeria monocytogenes shedding in a herd of dairy cattle. J of Theoretical Biology. 2007, 245: 44-58.

Tauer, L. W., Nightingale, C.R., Ivanek, R., Gröhn, Y.T., and Wiedmann, M.: Optimal levels of inputs to control Listeria monocytogenes contamination at a smoked fish plant. Agribusiness: an International Journal. 2007, 23: 229-244.

Haugan, T., Gaustad, A.H., Reksen, O., Gröhn, Y. T., and Hofmo, P.O.: Fertility results of artificial insemination performed with liquid boar semen stored in X-cell? versus BTS extender. Reprod Domest Anim. 2007, 42:94-9.

Wang, C., Turnbull, B., Gröhn, Y. T., and Nielsen, S.S.: Nonparametric estimation of ROC curves based on Bayesian models when the true disease state is unknown. Journal of Agricultural, Biological, and Environmental Statistics. 2007, 12, 128-¬146.

Ho, A. J., Ivanek,R. Gröhn, Y. T., Nightingale, K.K, and Wiedmann, M.: Listeria monocytogenes fecal shedding in dairy cattle shows high levels of day-to-day variation and includes outbreaks and sporadic cases of shedding of specific L. monocytogenes subtypes. Prev Vet Med. 2007, 80: 287-305.

Wilson,D.J., Mallard, B.A., Burton, J.J., Schukken, Y.H., and Gröhn, Y.T.: Milk and serum J5-specific antibody responses, milk production change and clinical effects following intramammary Escherichia coli challenge for J5 vaccinate and control cows. Clinical and Vaccine Immunology, 2007, 14: 693-699.

Wilson,D.J., Gröhn, Y.T., Bennet, G.J., Schukken, Y.H., and Spatz, J.: Comparison of J5 vaccinates and controls for incidence, etiologic agent, clinical severity, and survival in the herd following naturally occurring cases of clinical mastitis. J. Dairy Sci., 2007, 90: 4282-4360.

Bar, D., Gröhn, Y. T., Gonzalez, R.N., Hertl, J.A., Schulte, H.F., Bennett, G.J., Tauer., L.., Schukken, Y.H.: Effect of repeated episodes of generic clinical mastitis on milk yield in dairy cows J. Dairy Sci., 2007, 90: 4643-4653.

Gröhn, Y.T., Hertl, J.A., Ivanek, R., Abou-Zeid, K., and Wiedmann, M.: How university researchers can contribute to farm-to-table risk assessment. Foodborne Pathogens and Disease , 2007, 4: 527-537.

Chapagain, P*., Van Kessel, J.A., Karns, J.S., Wolfgang,D.R., Schukken, Y.H. Gröhn, Y.T.: A mathematical model of the dynamics of Salmonella Cerro infection in a US dairy herd. Epidemiology and Infection, 2008, 136: 263-272.

Mitchell, R.M., Whitlock, R.H., Stehman, S.M., Benedictus, A., Chapagain, P., Gröhn, Y.T., and Schukken, Y.H.: Simulation modeling to evaluate the persistence of Mycobacterium avium subsp. paratuberculosis (MAP) on commercial dairy farms in the United States. Prev Vet Med, 2008, 83: 360-380.

Bar, D., Gröhn, Y. T., Gonzalez, R.N., Hertl, J.A., Schulte, H.F., Bennett, G.J., Tauer., L.., Schukken, Y.H.: Effect of repeated episodes of generic clinical mastitis on culling in dairy cows J. Dairy Sci., 2008, 91: 2196-2204.

Bar, D., Tauer, L.W., Bennett, G., González, R.N., Hertl, J.A., Schukken, Y.H., Schulte, H.F., Welcome, F.L, and Gröhn, Y.T.: The cost of generic clinical mastitis in dairy cows as estimated using dynamic programming. J. Dairy Sci., 2008, 91: 2205-2214.

Scaria, J., Raghavan, U.M., Palaniappan, Chiu, D., Phan, J.A., Ponnala, L., McDonough, P., Gröhn, Y.T., Porwollik, S., McClelland, M., Chiou, C.-S., Chu, C., and Chang, Y.F.: Microarray for molecular typing of Salmonella enterica serovars. Molecular & Cellular Probes. 2008, 22: 238-243.

Lu, Z., Mitchell, R.M., Smith, R.L., Van Kessel, J.S., Chapagain, P.P, Schukken, Y.H., and Gröhn, Y.T.: The Importance of Culling in Johne’s Disease. J. of Theoretical Biology. 2008, 245: 135-146.

Lanzas, C., Brien, S., Ivanek, R. Lo, Y., Chapagain, P., Ray, K.A., Ayscue, P., Warnick., L.D., and Gröhn, Y.T.: The effect of heterogeneous infectious period and contagiousness on the dynamics of Salmonella transmission. Epidemiology and Infection. 2008, 136, 1496-1510.

Lanzas, C., Warnick., L.D., Ivanek, R., Ayscue, P., Nydam, D., McDonough, P., and Gröhn, Y.T.: The risk and control of Salmonella outbreaks in calf-rearing operations. Veterinary Research. 2008: 39:61.

Wilson,D.J., Gröhn, Y.T., Bennet, G.J., Gozalez,R.N., Schukken, Y.H., and Spatz, J.: Milk Production Change Following Clinical Mastitis and Reproductive Performance Compared Among J5 Vaccinated and Control Dairy Cattle. J. Dairy Sci. 2008, 91: 3969-3879.

N. Fall, Gröhn, Y.T. Forslund, K., Essen-Gustafsson, B., Niskanen,R. and Emanuelson, U.: An observational study on early-lactation metabolic profiles in Swedish organically and conventionally managed dairy cows. J. Dairy Sci. 2008, 91: 3983-3992.

Ivanek, R,, Gröhn, Y.T., Wells, M.T., Raengpradub, S., Kazmierczak, M. and Wiedmann, M.: Extreme value theory in analysis of differential expression in microarrays where either only up- or down-regulated genes are relevant or expected. Genetical Research. 2008, 90: 347-361.

Fraser, D. R., McGregor, D.D., Gröhn, Y.T.: Career paths of alumni of the Cornell Leadership Program for veterinary students. The Veterinary Record. 2008; 163: 750 - 756.

Bar, D., Tauer, L.W., Bennett, G., González, R.N., Hertl, J.A., Schukken, Y.H., Schulte, H.F., Welcome, F.L, and Gröhn, Y.T.: Use of a dynamic programming model to estimate the value of clinical mastitis treatment and prevention options utilized by dairy producers. Agric. Systems. 2009, 99:6-12.

Wilson,D.J.,* Mallard, B.A., Burton, J.L., Schukken, Y.H., and Gröhn, Y.T..: Association of Escherichia coli J5 -Specific Serum Antibody Responses with Clinical Mastitis Outcome for J5 Vaccinate and Control Dairy Cattle. Clinical and Vaccine Immunology. 2009, 16: 209-217.

Ayscue, P*., Lanzas, C., Ivanek, R., and Gröhn Y.T.: Modeling Escherichia coli O157:H7 Population Dynamics in Feedlots. Foodborne Pathogens and Disease. 2009. 6: 461-470.

Smith, R.L.*, Gröhn, Y.T., Pradhan, A., Whitlock, R.H., Van Kessel, J.S., Schukken, Y.H.: A longitudinal study for the impact of Johne’s Disease on milk production in individual cows. J. of Dairy Sci. 2009, 92: 2653-2661.

Davis, M. A., Baker, K.N.K., Call, D.R., Warnick L.D., Soyer, Y., Wiedmann, M., Gröhn, Y.T., McDonough P.L., Hancock D.D., and Besser, T. E.,: Multiple locus variable number of tandem repeats typing method for Salmonella enterica serovar Neport. J of Clin Microbiol., 2009, 47:1934-1938.

Janvilisri, T., Scaria, J., Thompson, A.D., Nicholson, A., Limbarg, B., Arroyo, L.G., Gleen Songer, G., J., Gröhn, Y.T., Yung-Fu Chang, Y.F.: Microarray Identification of Clostridium difficile core components and divergent regions associated with hosts origin. J of Bacteriology, 2009, 191: 3881-3891.

Pradhan, A., Ivanek, R., Gröhn, Y.T., Abou-Zeid, K., and Wiedmann, M.: Quantitative risk assessment for Listeria monocytogenes in selected categories of deli meats: impact of lactate-diacetate on listeriosis cases and deaths. J. of Food Protection. 2009, 75: 978-989.

Schukken, Y.H, Hertl, J.A., Bar, D., Bennett, G.J., Gonzalez, R.N., Rauch, B., Santisteban, C. Schulte, H.F., Tauer., L.., Welcome F.L., Gröhn, Y. T..: Effects of repeated Gram-Positive and Gram-Negative Clinical Mastitis Episodes on Milk Yield loss in Holstein Dairy Cows. J. of Dairy Sci. 2009, 92: 3091-3105.

Alexander, K. A.*, Warnick L.D., Cripps, C.J., McDonough, P.L., Gröhn, Y.T., Wiedmann, M., Reed, K.E., James, K.L., Soyer, Y., and Ivanek, R.: Fecal shedding, antimicrobial resistance, and serological response to Salmonella Typhimurium in calves on two dairy herds in the Northeast U.S. JAVMA. In Press.

Cummings, K.J. Warnick, L.D., Gröhn, Y.T., McDonough, P.L. Alexander, K.A., Cripps, C.J., Reed, K.E.: The Duration of fecal Salmonella shedding following clinical disease among dairy cattle in the northeastern USA. Prev Vet Med, In press.

Lu, Z.*, Gröhn, Y.T., Smith, R.L., Wolfgang, D.R., Van Kessel, J.S., and Schukken, Y.H: Assessing the potential impact of Salmonella vaccine in an endemically infected dairy herd. J. of Theoretical Biology. In press.